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Most relevant scientific articles
• Estruch R., Martínez-González M.A., Corella D., Salas-Salvadó J., Fito M., Chiva-Blanch G. et
al. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: A prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial. The Lancet Diabetes and Endocrinology. 2016.
• Smith C.E., Coltell O., Sorli J.V., Estruch R., Martínez-González M.A., Salas-Salvado J. et al. Associations of the MCM6-rs3754686 proxy for milk intake in Mediterranean and American populations with cardiovascular biomarkers, disease and mortality: Mendelian randomization. Scientific Reports. 2016;6.
• Corella D., Coltell O., Sorli J.V., Estruch R., Quiles L., Martínez-González M.A. et al. Polymorphism of the transcription factor 7-like 2 gene (TCF7L2) interacts with obesity on type-2 diabetes in the Predimed study emphasizing the heterogeneity of genetic variants in type-2 diabetes risk prediction: Time for obesity-specific genetic risk scores. Nutrients. 2016;8(12).
• Barragan R., Coltell O., Asensio E.M., Francés F., Sorli J.V., Estruch R. et al. MicroRNAs and drinking: Association between the pre-miR-27a rs895819 polymorphism and alcohol consumption in a mediterranean population. International Journal of Molecular Sciences. 2016;17(8).
• Corella D., Asensio E.M., Coltell O., Sorli J.V., Estruch R., Martínez-González M. et al. CLOCK gene variation is associated with incidence of type-2 diabetes and cardiovascular diseases in type-2 diabetic subjects: Dietary modulation in the PREDIMED randomized trial. Cardiovascular Diabetology. 2016;15(1).
Hightlights
Our research group has obtained important results in the study of the genetics of obesity and its interaction with environmental factors, through its participation in different national and international projects, that will be published in 2017. Among the published results, we would like to highlight the report for the first time regarding the use of stratum-specific genetic risk scores (GRS) to increase the predictive value of
these markers. Specifically, we have published that the best GRS to predict type 2 diabetes are different depending on whether the person is obese or not. Also in our pioneer work, we have demonstrated the association between variations in the clock gene and the incidence of type-2 diabetes and stroke. In addition, we have conducted an international study of Mendelian randomization and participated in other international consortia such as CHARGE in other Medellan randomization works. In these studies, we have used genetic markers as instrumental variables of food consumption. In parallel, we have described for the first time a genetic marker in a microRNA associated with alcohol consumption. We have expanded the line of epigenetics by obtaining several funded projects through which we are studying the effect
of DNA methylation on obesity and cardiovascular risk, as well as the influence of diet and physical
activity on changes in methylation. We have participated in new clinical trials with the industry, as well
as in the development of clinical guidelines. Participation in conferences through invited lectures has
been remarkable, both nationally and internationally. Moreover, we have carried out extensive scientific outreach activities in television, radio and press media. The group has carried out training activities giving several specific courses and masters, including the defense of 4 Doctoral Theses. Dr. Corella, coordinator of the Healthy Campus at the University of Valencia, has participated in several health promotion activities.
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