Page 81 - CIBEROBN2016-ENG

Most relevant scientific articles
• Díaz-Rua R., Van Schothorst E.M., Keijer J., Palou A., Oliver P. Isocaloric high-fat feeding directs hepatic metabolism to handling of nutrient imbalance promoting liver fat deposition. International Journal of Obesity. 2016.
• Lauria F., Siani A., Pico C., Ahrens W., Bammann K., De Henauw S. et al. A common variant and the transcript levels of MC4R gene are associated with adiposity in children: The IDEFICS study. Journal of Clinical Endocrinology and Metabolism. 2016;101(11):4229-4236.
• Castro H., Pomar C.A., Palou A., Pico C., Sánchez J. Offspring predisposition to obesity due to maternal-diet-induced obesity in rats is preventable by dietary normalization before mating. Molecular Nutrition and Food Research. 2016.
• Reynes B., Serrano A., Petrov P.D., Ribot J., Chetrit C., Martínez-Puig D. et al. Anti-obesity and insulin-sensitising effects of a glycosaminoglycan mix. Journal of Functional Foods. 2016;26:350-362.
• Cifre M., Díaz-Rua R., Varela-Calvino R., Reynes B., Pericas-Beltran J., Palou A. et al. Human peripheral blood mononuclear cell in vitro system to test the efficacy of food bioactive compounds: Effects of polyunsaturated fatty acids and their relation with BMI. Molecular Nutrition and Food Research. 2016.
Hightlights
During the year 2016, the group headed by Prof. Andreu Palou has participated in different projects and research networks of excellence mainly focused in the identification of predictive biomarkers of obesity and nutrition, and in the effects of food bioactive compounds useful for substantiation of functional claims. As part of the European project I.FAMILY the group has contributed to the identification of obesity biomarkers in children. In the National Plan, the group has initiated the INTERBIOBES project (AGL2015- 67019-P) in which interaction between nutrients and food bioactives for prevention of obesity and its complications is being analysed. The group is also involved in three private projects with Alimentómica S.L. (two of them with the direct implication of CIBER), in two national excellence research networks (MARCASALUD and CaRed) and in a COST Action on carotenoid research and applications in agro-food and health (EUROCAROTEN). Moreover, they group has worked in 4 projects from the University of the Balearic Islands aimed to the research on biomarkers useful in obesity and functional food studies, and to the use of bioinformatics tools in the identification of these biomarkers (BIOTHERM, IBIFLEX, MECALI y BIOBIP). During this period, a patent (P201430428) in which the group identifies a nutrigenomic biomarker, in blood, able to predict since early ages predisposition to develop obesity has been accepted; this patent has been deposited in Russia. In addition, during this period two human studies have been initiated, METAHEALTH- test and COLEX-test, aimed to identify biomarkers of clinical interest in blood cells.
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