Page 31 - CIBEROBN-2015-eng

Most relevant scientific articles
Research Groups
ZHOU L., PARK S.-Y., XU L., XIA X., YE J., SU L. ET AL. Insulin resistance and white adipose tissue inflammation are un- coupled in energetically challenged Fsp27-deficient mice. Nature Communications. 2015;6.
LóPEZ-VILLAR E., MARTOS-MORENO G.A., CHOWEN J.A., OKA- DA S., KOPCHICK J.J., ARGENTE J.. A proteomic approach to obesity and type 2 diabetes. Journal of Cellular and Mole- cular Medicine. 2015;19(7):1455-1470.
CASTRO-GONZáLEZ D., FUENTE-MARTíN E., SáNCHEZ-GARRI- DO M.A., ARGENTE-ARIZON P., TENA-SEMPERE M., BARRIOS V. ET AL. Increased prepubertal body weight enhances lep- tin sensitivity in proopiomelanocortin and neuropeptide y neurons before puberty onset in female rats. Endocrinolo- gy. 2015;156(4):1272-1282.
Highlights
This past year we described the first human muta- tions in the metaloprotease PAPP-A2 that results in post-natal growth retardation and modifications in body composition (in press and patent pending). This protease specifically cleaves IGF binding pro- tein (IGFBP) 3 and IGFBP5. These patients have extremely high circulating levels of the components that form the 150 kDA ternary complex: IGF-I, IGF.II, IGFBP-3, IGFBP-5 and the acid labile subunit (ALS), but very low levels of free/bioactive IGF-I. These fin- dings not only describe a new syndrome, but help to advance our understanding of the physiology of
MELA V., DIAZ F., LóPEZ-RODRíGUEZ A.B., VáZQUEZ M.J., GERTLER A., ARGENTE J. ET AL. Blockage of the neonatal leptin surge affects the gene expression of growth factors, glial proteins, and neuropeptides involved in the control of metabolism and reproduction in peripubertal male and fe- male rats. Endocrinology. 2015;156(7):2571-2581.
BURGOS-RAMOS E., CANELLES S., RODRíGUEZ A., GóMEZ-AM- BROSI J., FRAGO L.M., CHOWEN J.A. ET AL. Chronic central leptin infusion modulates the glycemia response to insulin administration in male rats through regulation of hepatic glucose metabolism. Molecular and Cellular Endocrinolo- gy. 2015;415:157-172.
the GH/IGF system. One of our current aims is to analyze how alterations in PAPP-A2 activity, as well as PAPPA activity, might explain the alterations of the GH/IGF axis in obese children.
The childhood obesity clinic continues to not only pro- vide adequate clinical care and behavioral treatment, but we are also advancing in our understanding of how to identify those children that may be at higher risk of developing insulin resistance. Recent results from studies including metabolomics have helped to identify potential new biomarkers (in press).
Institution: Servicio Madrileño de Salud · Contact: Hospital Infantil Universitario Niño Jesús Avenida Menéndez Pelayo, 65. 28009 Madrid · Tel.: 91 503 5939 · E.mail: [email protected]
CIBEROBN I Annual report 2015 I 31