Page 30 - CIBEROBN-2015-eng

Research Groups
Obesidad Infantil, Genética y Neuroendocrinología
Programme: Complications of Obesity / Physiopathology of the Homeostasis of Body Weight / Adipobiology / New Strategies and Biomarkers
Lead Researcher: Argente Oliver, Jesús
Group Members
STAFF MEMBERS: Canelles Ortiz, Sandra | Díaz González, Francisca.
ASSOCIATED MEMBERS: Argente Arizon, Pilar | Baquedano Caballero, Eva | Barrios Sabador, Vicente | Castro González, David | Chowen King, Julie Ann | Frago Fernández, Laura María | García Cáceres, Cristina | Granado García, Miriam | Martos Moreno, Gabriel Ángel | Muñoz Calvo, María Teresa | Pozo Román, Jesús.
Main lines of research
• Severe early onset childhood obesity: metabolic, hormonal, genetic, genomic and metabolomic as- pects. Clinical follow-up and study of more than 1300 children with severe early onset obesity.
• Relationship genotype/phenotype in the deve- lopment of secondary complications of obesity. Studies analyzing the impact of sex, ethnic group, etc., on the development of lipid, cardiac and car- bohydrate metabolism disorders.
• Importance of the GH/IGF-I axis in growth and body composition. Description and study of the first patients with mutations in the metaloprotea- se PAPP-A2 and its effects on the GH/IGF-I axis. Studies analyzing the role of proteases (PAPP-A and PAPP-A2) specific for certain IGF binding pro- teins in controlling the balance of the GH/IGF-I system in obese children.
• The role of hypothalamic astrocytes in physio- logical and pathophysiological metabolic con- trol. Analysis of the effect of metabolic factors (ghrelin and leptin) and nutritional factors (fruc- tose and fatty acids) on hypothalamic astrocytes and how this affects the neuroendocrine control of metabolism and the possible development of leptin and insulin resistance. Determination of the protective effects of sex steroids and resveratrol on astrocytes.
• Long-term metabolic effects of early dietary and hormonal modifications. Studies involving the effects of maternal and/or neonatal nutrition, stress and modifications in hormones (leptin and sex steroids) on adult metabolism.
• Interaction of leptin and insulin signaling pa- thways in the development of obesity associated complications.
30 I Annual report 2015 I CIBEROBN