Page 59 - CIBEROBN-2015-eng

Most relevant scientific articles
Research Groups
LOBO M.V.T., ARENAS M.I., HUERTA L., SACRISTáN S., Pé- REZ-CRESPO M., GUTIERREZ-ADAN A. ET AL. Liver growth factor induces testicular regeneration in EDS-treated rats and increases protein levels of class B scavenger recep- tors. American Journal of Physiology - Endocrinology and Metabolism. 2015;308(2):E111-E121.
CERRATO F., FERNáNDEZ-SUAREZ M.E., ALONSO R., ALONSO M., VáZQUEZ C., PASTOR O. ET AL. Clínically used selecti- ve oestrogen receptor modulators increase LDL receptor activity in primary human lymphocytes. British Journal of Pharmacology. 2015;172(5):1379-1394.
MARTíNEZ-BOTAS J., RODRíGUEZ-áLVAREZ M., CERECEDO I., VLAICU C., DIEGUEZ M.C., GóMEZ-CORONADO D. ET AL. Identification of novel peptide biomarkers to predict sa-
Highlights
During 2015, the CNO group has made many pro- gresses in the development of various lines of re- search on cholesterol metabolism, the actions and effects of certain micronutrients and complications of obesity, such as diabetes and infertility. As for the results, we have shown that alterations in the biosynthesis of cholesterol can lead to replication stress and DNA damage, with consequences in genomic stability, being the first time a connection between the cholesterol metabolism and the intra- cellular deoxyribonucleotide pool is established. Furthermore, it has been shown that firs and se- cond generation antipsychotics as well as selective estrogen receptor modulators (SERMs), which are amines with amphiphilic nature, alter the intrace- llular cholesterol traffic and produce lipidosis. This alteration can be alleviated by dietary polyphenols that stimulate the formation and secretion of exo- somes. It has been also delineated the mechanism by which SERMs stimulate LDL receptor expression and activity. This explains the cholesterol lowe-
fety and efficacy of cow’s milk oral immunotherapy by peptide microarray. Clínical and Experimental Allergy. 2015;45(6):1071-1084.
MARTíN SáNCHEZ C., PéREZ MARTíN J.M., JIN J.-S., DAVALOS A., ZHANG W., DE LA PENA G. ET AL. Disruption of the me- valonate pathway induces dNTP depletion and DNA da- mage. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2015;1851(9):1240-1253.
CANFRAN-DUQUE A., PASTOR O., REINA M., LERMA M., CRUZ-JENTOFT A.J., LASUNCION M.A. ET AL. Curcumin miti- gates the intracellular lipid deposit induced by antipsycho- tics in vitro. PLoS ONE. 2015;10(10).
ring effect of SERMs. Regarding infertility, we have shown that HSL, 3β-HSD and SR-BI receptor, which are all involved in the metabolism of lipids, also play an important role in spermatogenesis. In the field of biomarkers, we have identified two groups of pepti- des bound to IgE-binding proteins that can be used as novel biomarkers to predict the safety and effica- cy of CM-OIT before starting treatment. In addition, a MALDI-TOP-based method has been developed for the quantitative lipidomic analysis of plasma and plasma lipoproteins. Various collaborative stu- dies have been performed for the identification and characterization of microRNAs involved in the regu- lation of lipid metabolism.
Several AES projects remain active, from both ISCI- II and MINECO, as well as from private fundations. Finally, this group is involved in the consortium ALI- BIRD-CM entitled “Functional Foods and effective nutritional strategies for the prevention and treat- ment of chronic diseases”.
Institution: Servicio Madrileño de Salud · Contact: Hospital Ramón y Cajal. Ctra. de Colmenar, km 9.1 28034 Madrid · Tel.: 91 336 80 77 · E.mail: [email protected] · Website: http://www.ciberobn.es/
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