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lEAD RESEARCHER
Argente Oliver, Jesús
Servicio Madrileño de Salud
Hospital Infantil Universitario Niño Jesús
Avda. Menéndez Pelayo, 65 28009 Madrid
(+34) 91 503 59 39 [email protected] group Website
GROUP MEMBERS
Staff members: Canelles Ortiz, Sandra | Díaz González, Francisca | Guerra Cantera, Santiago
Associated members: Argente Arizón, Pilar | Baquedano Caballero, Eva | Barrios Sabador, Vicente | Castro González, David | Chowen King, Julie Ann | Frago Fernández, Laura María | García Cáceres, Cristina | Granado García, Miriam | Martos Moreno, Gabriel Ángel | Muñoz Calvo, María Teresa | Pozo Román, Jesús
Main lines of research
• Severe early onset childhood obesity: metabolic, hormonal, genetic, genomic, metabolomic and microbiota aspects. Clinical follow-up and study of more than 1300 children with severe early onset obesity.
• Relationship genotype/phenotype in the development of secondary complications of obesity. Studies analyzing the impact of sex, ethnic group, etc., on the development of lipid, cardiac and carbohydrate metabolism disorders.
• Importance of the GH/IGF-I axis in growth and body composition. Description and study of the first patients with mutations in the metaloprotease PAPP-A2 and its effects on the GH/IGF-I axis. Studies analyzing the role of proteases (PAPP-A and PAPP-A2) specific for certain IGF binding proteins in controlling the balance of the GH/IGF-I system in obese children.
• The role of hypothalamic astrocytes in physiological and pathophysiological metabolic control. Analysis of the effect of metabolic factors (ghrelin and leptin) and nutritional factors (fructose and fatty acids) on hypothalamic astrocytes and how this affects the neuroendocrine control of metabolism and the possible development of leptin and insulin resistance. Determination of the protective effects of sex steroids, IGF-I and resveratrol on astrocytes.
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PROGRAMMES
P2 | P3 | P5 | P6