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• Long-term metabolic effects of early dietary and hormonal modifications. Studies involving the effects of maternal and/or neonatal nutrition, stress and modifications in hormones (leptin and sex steroids) on adult metabolism.
• Interaction of leptin and insulin signaling pathways in the development of obesity associated complications.
Most relevant scientific articles
• Dauber A., Munoz-Calvo M.T., Barrios V., Domene H.M., Kloverpris S., Serra-Juhe C. et al. Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability. EMBO Molecular Medicine. 2016.
• Munoz-Calvo M.T., Barrios V., Pozo J., Chowen J.A., Martos-Moreno G.A., Hawkins F. et al. Treatment with recombinant human insulin-like growth factor-1 improves growth in patients with PAPP-A2 deficiency. Journal of Clinical Endocrinology and Metabolism. 2016;101(11):3879-3883.
• Mastrangelo A., Martos-Moreno G.A., García A., Barrios V., Rupérez F.J., Chowen J.A. et al. Insulin resistance in prepubertal obese children correlates with sex-dependent early onset metabolomic alterations. International Journal of Obesity. 2016;40(10):1494-1502.
• Fuente-Martín E., García-Cáceres C., Argente-Arizón P., Díaz F., Granado M., Freire-Regatillo A. et al. Ghrelin Regulates Glucose and Glutamate Transporters in Hypothalamic Astrocytes. Scientific Reports. 2016;6.
• Chowen J.A., Argente-Arizón P., Freire-Regatillo A., Frago L.M., Horvath T.L., Argente J. The role of astrocytes in the hypothalamic response and adaptation to metabolic signals. Progress in Neurobiology. 2016.
Hightlights
Our discovery of a new syndrome, characterized by growth failure and skeletal abnormalaties, due to a mutation in the gene for the protease PAPP-A2 has led to a better understanding of the IGF-I system in human growth and development. This discovery has been filed for patent approval in the USA. We have also obtained data regarding the response to exogenous IGF-I treatment, including not only longitudinal growth, but also metabolic factors. Funding of new project has been obtained to further analyze this new mechanism in human physiology. This project is a coordinated project with collaborators in Málaga and will include a close collaboration with groups in Denmark and Canada.
Our genetic and genomic studies have resulted in the identification of new genes involved in human obesity and these genes and their functions are currently under investigation.
Metabolomic studies have identified biomarkers that may be more useful for the prediction of the onset of insulin resistance in obese children than the currently used methods in the clinical setting. These studies have also identified sex differences in the metabolic markers even in prepubertal children.
OBN
Research groups 37