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- Nutritional and genetic determinants of the development of different obesity phenotypes; association
of these phenotypes with diseases risk and mortality.
• Nutrition, diet and cancer
- Pro-oxidant and antioxidant nutritional factors and their influence on carcinogenesis: the role of estrogens.
- Dietary patterns defined a priori and a posteriori and incidence and recurrence of cancer.
Most relevant scientific articles
• Ruiz-Canela M., Toledo E., Clish C.B., Hruby A., Liang L., Salas-Salvadó J. et al. Plasma branched- chain amino acids and incident cardiovascular disease in the PREDIMED Trial. Clinical Chemistry. 2016;62(4):582-592.
• Cordani M., Oppici E., Dando I., Butturini E., Dalla Pozza E., Nadal-Serrano M. et al. Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition. Molecular Oncology. 2016.
• Estruch R., Martínez-González M.A., Corella D., Salas-Salvadó J., Fito M., Chiva-Blanch G. et
al. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: A prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial. The Lancet Diabetes and Endocrinology. 2016.
• Navarrete-Munoz E.M., Wark P.A., Romaguera D., Bhoo-Pathy N., Michaud D., Molina-Montes E. et al. Sweet-beverage consumption and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC). American Journal of Clinical Nutrition. 2016;104(3):760-768.
• Di Cesare M., Bentham J., Stevens G.A., Zhou B., Danaei G., Lu Y. et al. Trends in adult body-mass index in 200 countries from 1975 to 2014: A pooled analysis of 1698 population-based measurement studies with 19.2 million participants. The Lancet. 2016;387(10026):1377-1396.
Hightlights
During 2016 our group has completed the recruitment of participants for the PREDIMED-PLUS study, recruiting a total of 335 individuals. Within the PREDIMED-PLUS study, we continued to lead the Core Laboratory of Electrocardiography, collecting and interpreting all electrocardiograms generated for the entire PREDIMED-PLUS study and participated in the sub-studies of densitometry and echocardiography. We have requested numerous research projects, including an NIH project R1 (USA) in collaboration with other CIBER-OBN groups and researchers from the University of Atlanta (Dr. Alvaro Alonso), to study the atrial fibrillation substrate in participants Of the PREDIMED-PLUS study (not yet granted). We have also obtained funding through the Ministry of Economy and Competitiveness (MINECO) to initiate the project ESTROGENE MODULATOR EFFECT ON THE FUNCTIONALITY OF THE ADIPOSE TISSUE AND ITS INFLUENCE ON THE CARDIOVASCULAR RESPONSE IN AN INFLAMMATORY ENVIRONMENT (SAF2016-80384-R). We are currently conducting statistical analyses to publish two articles with PREDIMED-1 data related to diet and obesity, and we have two approved proposals for analysis with data from the PREDIMED-PLUS study once data is available. The Principal Investigator of the group, Dr. Fiol, continues as Scientific Director of the Institute of Health Research of the Balearic Islands.
OBN
Research groups 55