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• Programmes for personalized physical activity present at the hospital and in areas of free time supervised by pediatricians. Programmes for personalized home physical activity implemented via telematics.
In the study area of cardiometabolic and renal complications:
• Study of biomarkers of cardiometabolic risk.
• Study of the mechanisms of podocyte damage as the origin of renal damage in obesity.
• Study of genetic markers (epigenetics, proteomics, genomics) in the risk of developing obesity and its
complications.
Most relevant scientific articles
• Lurbe E., Agabiti-Rosei E., Cruickshank J.K., Dominiczak A., Erdine S., Hirth A. et al. 2016 European Society ofHypertension guidelines for themanagement of high blood pressure in children and adolescents. Journal of Hypertension. 2016;34(10):1887-1920.
• Redon P., Grassi G., Redon J., Álvarez-Pitti J., Lurbe E. Sympathetic neural activity, metabolic parameters and cardiorespiratory fitness in obese youths. Journal of Hypertension. 2016.
• Lurbe E., Torro M.I., Álvarez-Pitti J., Redon P., Redon J. Central blood pressure and pulse wave amplification across the spectrum of peripheral blood pressure in overweight and obese youth. Journal of Hypertension. 2016;34(7):1389-1395.
• Lurbe E., Redon J. Isolated Systolic Hypertension in Young People Is Not Spurious and Should Be Treated: Con Side of the Argument. Hypertension. 2016;68(2):276-280.
• Urdinguio R.G., Torro M.I., Bayon G.F., Álvarez-Pitti J., Fernández A.F., Redon P. et al. Longitudinal study of DNA methylation during the first 5 years of life. Journal of Translational Medicine. 2016;14(1).
Hightlights
SCIENTIFIC:
a) An applied methodology for our population of obese children and adolescents has been developed for the evaluation of the vascular phenotype, ambulatory blood pressure, peripheral as well as aortic, activity of the sympathetic nervous system and metabolic evaluation (insulin resistance, hyperglycemia, metabolomics); b) application of genomic, epigenetic, metabolomics and proteomics techniques in the umbilical cord for searching biomarkers on the evaluation of the risk of obesity and cardio metabolic alterations.
INNOVATION AND TRANSFER:
a) Development of algorithms of the cardiorespiratory fitness for the personalised physical activity of overweight, children and adults, using “wearables” without using calorimeter. This development lead to the participation within the BIOTEI-LAB, belonging to the KIC eit-HEALTH in the node of the Polytechnic University of Madrid. This technology, currently being registered, is going to be applied in the 4-year project PROMETEO (Funding of 268.000€) for the study of the temporal evolution of metabolic alterations and the activity of the sympathetic nervous system. b) Achievement of the European project within the call IMI2 named Big Data4Big Heart, using methodology of big data for a better knowledge and segmentation of cardio metabolic alterations.
GUIDELINES:
There have been two participations in European Guidelines. The European Guidelines of Hypertension in Children and Adolescents of the European Society of Hypertension have been coordinated by the group leader (J Hypertens 2016). Apart from that there has been a participation as an author in the European Guidelines of the Evaluation of Cardiovascular Risk of the European Society of Cardiology (Eur Heart Journal, 2016).
OBN
Research groups 71