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heart disease patients. J Clin Lipidol. 2016 Sep-Oct;10(5):1163-71. -Leon-Acuña A, et al., Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study. Cardiovasc Diabetol. 2016 Apr 19;15:68).
Finally, results are published showing that the consumption of the two healthy diets administered in the CORDIOPREV study modify the composition of the intestinal microbiota. On the one hand, it is shown that the consumption of the Mediterranean diet counteracts the decrease of the saccharolytic flora observed in patients with metabolic syndrome (J Nutr Biochem. 2016 Jan;27:27-31.),
As well as increases the abundance of Roseburia, whereas the low fat diet favors the growth of F. prausnitzii, whose abundance is low in diabetic people (J Clin Endocrinol Metab. 2016 Jan;101(1):233-42).
Most relevant scientific articles
• Blanco-Rojo R., Alcalá-Díaz J.F., Wopereis S., Pérez-Martínez P., Quintana-Navarro G.M., Marín C.
et al. The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2 years of intervention: the CORDIOPREV-DIAB randomised clinical trial. Diabetología. 2016;59(1):67-76.
• López-Moreno J., Quintana-Navarro G.M., Delgado-Lista J., García-Ríos A., Delgado-Casado N., Camargo A. et al. Mediterranean Diet Reduces Serum Advanced Glycation End Products and Increases Antioxidant Defenses in Elderly Adults: A Randomized Controlled Trial. Journal of the American Geriatrics Society. 2016;64(4):901-904.
• Blanco-Rojo R., Delgado-Lista J., Lee Y.-C., Lai C.-Q., Pérez-Martínez P., Rangel-Zuniga O. et al. Interaction of an S100A9 gene variant with saturated fat and carbohydrates to modulate insulin resistance in 3 populations of different ancestries. American Journal of Clinical Nutrition. 2016;104(2):508-517.
• Pérez-Martínez P., Alcalá-Diaz J.F., Kabagambe E.K., García-Ríos A., Tsai M.Y., Delgado-Lista J. et al. Assessment of postprandial triglycerides in clinical practice: Validation in a general population and coronary heart disease patients. Journal of Clinical Lipidology. 2016.
• Haro C., Montes-Borrego M., Rangel-Zuniga O.A., Alcalá-Díaz J.F., Gámez-Delgado F., Pérez-Martínez P. et al. Two healthy diets modulate gut microbial community improving insulin sensitivity in a human obese population. Journal of Clinical Endocrinology and Metabolism. 2016;101(1):233-242.
Hightlights
During the year 2016 our group has maintained the high level of excellence, accredited in the past. This fact is supported by the following milestones:
We have published 41 articles (JCR), with a high percentage of leadership in these publications, and an index of more than 140 points cumulative impact. In addition, during the year of 2016, we have developed a total of 7 research projects of national competitive calls, and a European project (Power2DM), and we have obtained the financing of a new European project (PCIN-0156-2016). Within the catchment of the Group’s resources,
it should be noted the creation of 2 new clinical trials as well as the participation in 14 clinical trials. From the point of view of mobility, we have been receiving several visiting researchers. In relation to the human resources we currently enjoy a contract PFIS, FPI, Sara Borrell, Juan de la Cierva, two Miguel Servet, one Nicolás Monarde, a contract with internal medicine to enhance the research work of the UGC and eight PhD theses have been defended with the highest rating, which indicates the quality of training of our group. Moreover, we have also participated in the development of a consensus document. Finally, highlight that we have finished an electronic platform for the management of research projects “Virtual platform for the management and exploitation of research projects, with application to nutritional intervention studies (Pad- CRD)”, with copyright registration code RPI201599902441360 (Spain). This tool is added to the preliminary patents of previous years, which are still on.
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