Page 67 - CIBEROBN2016-ENG

Most relevant scientific articles
• Fernández-Suárez M.E., Escolá-Gil J.C., Pastor O., Davalos A., Blanco-Vaca F., Lasunción M.A. et al. Clinically used selective estrogen receptor modulators affect different steps of macrophage-specific reverse cholesterol transport. Scientific Reports. 2016;6.
• Casado M.E., Pastor O., García-Seisdedos D., Huerta L., Kraemer F.B., Lasunción M.A. et al. Hormone- sensitive lipase deficiency disturbs lipid composition of plasma membrane microdomains from mouse testis. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 2016;1861(9):1142-1150.
• Botella-Carretero J.I., Lafuente C., Montes-Nieto R., Balsa J., Vega-Pinero B., García-Moreno F. et al. Serum Bioavailable Vitamin D Concentrations and Bone Mineral Density in Women After Obesity Surgery. Obesity Surgery. 2016;26(11):2732-2737.
• Canfrán-Duque A., Barrio L.C., Lerma M., de la Pena G., Serna J., Pastor O. et al. First-generation antipsychotic haloperidol alters the functionality of the late endosomal/lysosomal compartment in vitro. International Journal of Molecular Sciences. 2016;17(3).
• Briand O., Touche V., Colin S., Brufau G., Davalos A., Schonewille M. et al. Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-regulation of Scavenger Receptor Class B, Type 1. Gastroenterology. 2016;150(3):650-658.
Hightlights
During 2016, the CNO group was involved in the study cholesterol metabolism, the actions and effects
of certain components of the diet and the complications of obesity, such as infertility. In the context of secondary alterations in lipid metabolism by xenobiotics, we have shown that certain antipsychotics alkalinize lysosomes, which explains the cellular retention of cholesterol they produce. Likewise, selective estrogen receptor modulators reduce cholesterol efflux from macrophages and alter the cholesterol reverse transport. Regarding the mechanisms of male infertility, we showed that HSL lipase deficiency produces large changes in the composition and functionality of lipid rafts, cell membrane microdomains where several receptors and signaling proteins are localized. In addition, a high throughput peptide microarray has been developed to identify food allergen epitopes. This group has been awarded with three projects from the AES ISCIII call (PI16 / 00154, Study of the role of lipid homeostasis in male infertility associated with obesity and its possible resolution after surgery and diet; PI16-00205, Effect of the intervention ‘Milk ladder’ in the development of tolerance and recognition of B-cell epitopes in children allergic to cow’s
milk proteins; DTS16 / 00131, Validation and implementation of a tool to predict the efficacy and safety
of the treatment of allergy to cow’s milk proteins by oral immunotherapy), the MINECO project SAF2015- 70747-R has been initiated (Study of the mechanisms and in vivo significance of xenobiotic-induced changes in intracellular lipid trafficking and its prevention by polyphenols) and the ALIBIRD-CM consortium (functional foods and effective nutritional strategies for the prevention and treatment of chronic diseases) is maintained.
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