Page 36 - CIBEROBN-2015-eng

Research Groups
Endocrinología Molecular
Programme: Complications of Obesity Lead Researcher: Casanueva Freijo, Felipe
Group Members
STAFF MEMBERS: Cabia Fernández, Begoña | Castelao Taboada, Cecilia | Castro País, Ana Isabel | Couselo Carreira, Marcos | Monteiro Andrade Sousa, Sara María.
ASSOCIATED MEMBERS: Amil Diz, María | Crujeiras Martínez, Ana Belén | Martínez Olmos, Miguel Ángel | Pardo Pérez, María | Pazos Randulfe, Yolanda | Peino García, Roberto | Peñalva Maqueda, Ángela | Pérez Cami- ña, Jesús | Seoane Camino, Luisa María.
Main lines of research
• Adipobiology.
• Obesity and Cancer.
• Nanotechnology applied to obesity.
• Development and validation of anti-obesity treat-
ments.
• Influence of obesity in models of cerebral ische-
mia.
• Obesidomic: identification and characterization
of new signals released by adipose and muscle tissue involved in the regulation of energy ho- meostasis: Proteomic Analysis of visceral and subcutaneous adipose tissue and its implications in the development and maintenance of obesity.
• Development and adaptation of proteomic tech- nologies (quantitative proteomics: DIGE, CILAIR) study these secretome of muscle and adipose tissue.
• Analysis of skeletal muscle secretome for the identification of regulatory signals of energy ho- meostasis.
• Characterization of Fetuin-A and Musclin/Osteo- crin as new peripheral signals involved in energy homeostasis.
• Study of the role of hormone irisin as a new target for the treatment of obesity and type 2 diabetes.
• Study of the physiological mechanisms respon- sible for the regulation of energy balance in the gastrointestinal tract. Role of ghrelin nesfatin a-1, gastricendogenous cannabinoid, signaling pa- thway activated by FNDC5 andmTOR/S6k1.
• Study of the effect of lactation on metabolism. Study of lipid metabolism in adipose tissue and gastrointestinal mechanisms.
36 I Annual report 2015 I CIBEROBN