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Most relevant scientific articles
Research Groups
ZANON-MORENO V., ZANON-MORENO L., ORTEGA-AZORIN C., ASENSIO-MARQUEZ E.M., GARCíA-MEDINA J.J., SANZ P. ET AL. Genetic polymorphism related to exfoliative glaucoma is also associated with primary open-angle glaucoma risk. Clí- nical and Experimental Ophthalmology. 2015;43(1):26-30.
GARCíA-ALOY M., LLORACH R., URPI-SARDA M., JAUREGUI O., CORELLA D., RUIZ-CANELA M. ET AL. A metabolomics-driven approach to predict cocoa product consumption by de- signing a multimetabolite biomarker model in free-living subjects from the PREDIMED study. Molecular Nutrition and Food Research. 2015;59(2):212-220.
VáZQUEZ-FRESNO R., LLORACH R., URPI-SARDA M., KHYME- NETS O., BULLO M., CORELLA D. ET AL. An NMR metabolo- mics approach reveals a combined-biomarkers model
Highlights
Our research group has continued to deepen the study of serveral omics (genomics, transcriptomics, epigenomics, metabolomics) and its application in Nutrigenomics. Several members of the group have been visiting researchers in the United States to learn the main tools for the integration of omics data. In relation to this integration, our research group has applied in 2015 with Dr. Ordovás from the Human Nutrition Research Center in Boston to a NIH (USA) research grant on the integration of omics in PREDI- MED participants focused on the incidence of Car- diovascular Disease Related Phenotypes. In parallel, we have continued conducting genetic analysis in the PREDIMED, ending the high density genotyping of the PREDIMED-Valencia Study and making the first GWAs thereof. We have also obtained funding for dense genotyping from Mapfre to carry out in GWAS in the PREDIMED PLUS-Valencia partici- pants. We have initiated the dense methylation of
in a wine interventional trial with validation in free-living individuals of the PREDIMED study. Metabolomics. 2015;11(4):797-806.
VALLS-PEDRET C., SALA-VILA A., SERRA-MIR M., CORELLA D., DE LA TORRE R., MARTíNEZ-GONZáLEZ M.A. ET AL. Mediterra- nean diet and age-related cognitive decline: A randomized clinical trial. JAMA Internal Medicine. 2015;175(7):1094- 1103.
URPI-SARDA M., BOTO-ORDONEZ M., QUEIPO-ORTUNO M.I., TULIPANI S., CORELLA D., ESTRUCH R. ET AL. Phenolic and microbial-targeted metabolomics to discovering and eva- luating wine intake biomarkers in human urine and plas- ma. Electrophoresis. 2015;36(18):2259-2268.
DNA samples by Illumina arrays to carry out a EWAS in a pilot case-control sample of CVD cases from the PREDIMED-Valencia study to provide preliminary data on the application of the NIH grant. We have collaborated on several metabolomic studies in our urine PREDIMED samples with Cristina Andrés (UB). Overall, our group has has acquired a hugh potential in the iomics integration in the epidemiological stu- dies. We have been invited to several international conferences related to omics, nutrigenomics and personalized medicine, among which we highlight the one held in November 2015 at the EMBL in Hei- delberg (Germany) focused on Personalized Health in collaboration with the Stanford University. Unfor- tunately this year has not been good in publications, which will be materialized in 2016. We conducted clinical trials, clinical guidelines and PhD student dregrees.
Institution: Universitat de València · Contact: Facultad de Medicina de Valencia Avda. Vicente Blasco Ibáñez, 15. 46010 Valencia · E.mail: [email protected]
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