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lEAD RESEARCHER
Ros Rahola, Emilio
Hospital Clínico y Provincial de Barcelona
C/ Villarroel, 170
08036 Barcelona
(+34) 93 227 93 83 [email protected] group Website
GROUP MEMBERS
Staff members: Cofan Pujol, Monserrat | Sala Vila, Aleix
Associated members: Alegret Jorda, Marta | Amor Fernández, Antonio Jesús | Laguna Egea, Juan Carlos | Merlos Roca, Manuel | Nuñez Lucas, Isabel | Ortega Martínez de Victoria, Emilio | Pérez Heras, Ana María | Roglans Ribas, Nuria | Sánchez Peñarroya, Rosa María | Valls Pedret, Cinta
Main lines of research
• Study of variants in genes of lipid metabolism that might illustrate the etiology of familial and polygenic hypercholesterolemia.
• Carotid ultrasound examination: a) associations between preclinical atherosclerosis and classical and emergent risk factors and dietary biomarkers; b) preclinical atherosclerosis in the pre-diabetic stage.
• Functionality of whole foods and dietary patterns: effects on the serum lipoprotein profile, 24-h ambulatory blood pressure, insulin resistance, markers of cholesterol absorption and synthesis, and dietary biomarkers.
• Specific projects within the PREDIMED study, for which the Group directed the nutritional intervention. Effects of PREDIMED diets on: a) cognitive decline alter intervention for 4 y; b) 5-y incidence of dementia; c) consumption of alpha-linolenic acid and mortality; d) fructose intake and mortality; e) changes in carotid plaque by ultrasound and MRI after intervention for 2 y.
• Randomized controlled trial WAHA (WAlnuts and Healthy Aging): effects of a diet enriched with walnuts
(15% of energy) for 2 y in comparison with a control diet on age-related cognitive decline and macular degeneration in 700 older persons. Other outcomes: 2-y changes in brain structure and function by functional MRI, carotid atherosclerosis, body composition, bone mineral density, 24-h ambulatory blood pressure, lipid profile and circulating inflammation markers, telomere length, and miRNAs related to lipid metabolism.
• Cognitive function evaluated by neuropsychological tests and functional brain MRI in familial hypercholesterolemia compared to moderate hypercholesterolemia and normolipidemia.
• Cholesterol absorption and synthesis as assessed by determination of plasma non-cholesterol sterols: quantification, genetic determinants, and effect on cardiovascular risk.
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PROGRAMMES
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