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• Associations of fatty acids profiles in total blood, total plasma and phospholipid fractions with cardiometabolic risk factors; carotid preclinical atherosclerosis; composition of “mitochondria-associated membranes” and intracellular signal transduction.
• Investigation of receptors heterodimeric with RXR (PPAR, FXR, LXR, etc.) and other nuclear receptors participating in energy metabolism in liver, adipose, and skeletal muscle tissues and in macrophages.
• Experimental models of metabolic syndrome in fructose-fed rats and rodent models of senescence. Molecular characterization.
Most relevant scientific articles
• Estruch R., Martínez-González M.A., Corella D., Salas-Salvadó J., Fito M., Chiva-Blanch G. et al. Effect of a high-fat Mediterranean diet on bodyweight and waist circumference: A prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial. The Lancet Diabetes and Endocrinology. 2016.
• Sala-Vila A., Díaz-López A., Valls-Pedret C., Cofan M., García-Layana A., Lamuela-Raventós R.-M. et
al. Dietary marine ω-3 fatty acids and incident sight-threatening retinopathy in middle-aged and older individuals with type 2 diabetes: Prospective investigation from the PREDIMED trial. JAMA Ophthalmology. 2016;134(10):1142-1149.
Hightlights
PROJECTS
• Title: Effect of daily ingestion of walnuts for 2 years on age-related cognitive decline and macular
degeneration in healthy elderly subjects: A randomized, single blind, dual center, controlled trial. WAHA study. PI: Emilio Ros. Funding Agency: California Walnut Commission. Budget: 695.640 euros. Duration 01/ JAN/2012 – 31/DEC/2016 (5 years)
• Title: Walnuts as an antiatherogenic food. Clinical and experimental assessment. PI: Aleix Sala Vila. Funding Agency: Instituto de Salud Carlos III. Budget: 110.715 euros. Duration: 01/01/2016 - 31/12/2018 (3 años). Contract number: PI15/01014.
• Title: Cell membrane changes induced by dietary long-chain omega-3 fatty acids and their link to chronic disease development. PI: Aleix Sala Vila. Funding Agency: Instituto de Salud Carlos III (programa Miguel Servet). Budget: 60.000 euros. Duration: 01/06/2013 - 31/12/2017 (4 años y 7 meses). Contract number: CP12/03299.
RESULTS
• The WAlnuts and Healthy Aging (WAHA) study was succesfully completed after follow-up for 2 years of 350 older participants submitted to a walnut dieta or a control diet. Data are being analyzed for publications in 2017.
• The PREDIMED database keeps providing insight into the associations between the Mediterranean diet and various health outcomes. During this year we have analysed the effects of the PRDIMED diets on an important health outcome, incident dementia, and the resulting paper has been submitted.
• The group has continued with the productive line of research of associations of fructose intake with cardiometablic risk.
• The PI has participated in important clinical guidelines (consensus document) of the European Atherosclerosis Society and the European Federation of Clinical Chemistry and Laboratory Medicine, which recommends non fasting for blood lipid analyses and has had a great impact inclinical laboratories worldwide.
OBN
Research groups 89