Page 21 - CIBEROBN-2015-eng

Scientific Programmes
Neurocognition and Environmental-Biological Factors in Extreme Weight conditions
Achievements of Sub-programme 1 (P4):
A.1) Extension and complete collection of clinical samples. Comparative analyses of data on psycho- pathological, emotional, neurocognitive, environ- mental and personality aspects in the Obese, similar food disorders and extreme weight situations. Phe- notypic characterisation in relation with BMI.
A.2) The transversal sub-programme currently has a total sample of 502 women in extreme weight situa- tions (113 AN, 20 low-weight controls, 119 normal weight controls, 16 overweight controls, 38 obese with nervous bulimia (BN) or binge eating disorder (BED), 51 obese with no eating disorder (ED) and 145 morbidly obese), either phenotypically charac- terised (neurocognition, smell-taste, clinically, acti- vity-sleep) in respect of biological markers and Bu- ffy-coat.
Over last year we went on performing and publi- shing studies analysing neurocognitive and senso- rial parameters with the data from the programme:
• ISLAM, MA ET AL. (2015). Olfaction in eating disor- ders and abnormal eating behavior: A Systematic Review. Frontiers in Psychology, 6:1431.
• WOLZ I ET AL. (2015). Emotion regulation in disor- dered eating: Psychometric properties of the Diffi- culties in Emotion Regulation Scale among Spanish adults and its interrelations with personality and cli- nical severity. Front Psychol.; 6:907.
A.3). Analysis of data on the mood, activity and qua- lity of life in extreme weight situation subjects.
• SAUCHELLI ET AL., (2016). Orexin and sleep quality in anorexia nervosa: Clínical relevance and influen- ce on treatment outcome. Psychoneuroendocrino- logy. 65:102-108.
B.1) Characterisation of patients with extreme wei- ght situations and with similar ED based on endo- crine-metabolic-genetic parameters (opioid system, endogenous cannabinoids, endogens, hormones and cardiovascular markers) and integrating mo- dels.
• BARJA-FERNáNDEZ ET AL. (2015). Circulating beta- trophin levels are increased in anorexia and decrea- sed in morbid obese women. J Clin Endocrinol Me- tab. 2015 Sep; 100 (9):E1188-96.
• PARDO ET AL. (2014). Association of irisin with fat mass, resting energy expenditure, and daily activity in conditions of extreme body mass index. Int J En- docrinol. 2014; 2014:857270.
• MAILLARD AM ET AL. (2015). 16p11.2 Locus modu- lates response to satiety before the onset of obesi- ty. Int J Obes (Lond). 2015 Dec 1. doi: 10.1038/ ijo.2015.247.
C.1) Analysis of the interaction between environ- mental-neurocognitive and biological factors (endo- crinal-metabolic-genetic-environmental functional channels) and integrating models. Determination of endophenotypes and shared vulnerabilities in sub- jects with extreme weight conditions and patterns of anomalous ingestion.
• FERNáNDEZ-ARANDA, F. ET AL. (2016) Smell-taste dysfunctions in extreme weight/eating conditions: analysis of hormonal and psychological interaction. Endocrine. 2016 Feb; 51(2):256-67.
• PASTOR ET AL. (2016) A Lower Olfactory Capacity Is Related to Higher Circulating Concentrations of En- docannabinoid 2-Arachidonoylglycerol and Higher Body Mass Index in Women. PLoS One. 2016 Feb 5; 11(2):e0148734.
• FAGUNDO, AB ET AL. (2015). Modulation of Hi- gher-order Olfaction Components on Executive Functions in Humans. PLOS One 2015 Jun 17; 10(6):e0130319.
• FERNáNDEZ-REAL JM, SERINO M, BLASCO G, PUIG J, DAUNIS-I-ESTADELLA J, RICART W, BURCELIN R, FERNáNDEZ-ARANDA F, PORTERO-OTíN M. (2015). Gut microbiota interacts with brain microstruc- ture and function. J Clin Endocrinol Metab. Oct 7:jc20153076. [Epub ahead of print].
CIBEROBN I Annual report 2015 I 21