Page 86 - CIBEROBN-2015-eng

Research Groups
Investigación y Desarrollo en Obesidad
y Enfermedades Asociadas
Programme: Complications of Obesity
Lead Researcher: Tinahones Madueño, Francisco
Group Members
STAFF MEMBERS: Clemente Postigo, Ma Mercedes | Coin Aránguez, Leticia | Martín Núñez, Gracia Ma | Morcillo Espina, Sonsoles | Oliva Olivera, Wilfredo | Picón César, Inmaculada Concepción
ASSOCIATED MEMBERS: Alcaide Torres, Juan | Barbarroja Puerto, Nuria | Bernal López, Ma Rosa | Cardona Díaz, Fernando | Castellano Castillo, Daniel | El Bekay, Rajaa | Fernández García, Diego | Fernández García, José Carlos | García Almeida, José Manuel | García Fuentes, Eduardo | Garrido Sánchez, Lourdes | Gómez Huelgas, Ricardo | López Siguero, Juan Pedro | Macías González, Manuel | Manchas Doblas, Isabel | Moreno Indias, Isabel | Queipo Ortuño, Ma Isabel | Roca Rodríguez, Ma del Mar
Main lines of research
• Obesity and related diseases. Our group is stud- ying the relationship between obesity and its re- lated metabolic diseases. We try to elucidate the mechanisms that protect some particular obese individuals who do not develop metabolic disea- ses or do it lately. Within these related diseases, we are focused on diabetes, postprandial lipide- mia and cancer.
• Adipose tissue biology. Our group is studying the expansion capacity of the adipose tissue and its relationship with insulin resistance. Thus, we are studying the neogenic capacity of the mesen- chymal cells from adipose tissue, the necrosis predisposition, autophagy and apoptosis as well as the pro-fibrotic capacity of the tissue, relating these factors to metabolic pathologies. Moreover, the group is studying lipogenic and angiogenic
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capacities of the different factors that modulate the expansion capacity of the adipose tissue and its relationship with the metabolic diseases. Study of the gut microbiota and related disea- ses. We are studying the bacterial profiles of the gut microflora within different pathologic situa- tions in order to establish its role in their origins and developments. Moreover, we are also stud- ying the microbiota changes that interventions with polyphenols cause and the changes produ- ced by the radiotherapy in oncologic patients. Study of the epigenetic profiles according to their relationships with obesity-diabetes and cancer-obesity. We are studying the epigene- tic modifications of the genes implicated in the molecular mechanisms of expression repression and of the transcription factors implicated in obe-
86 I Annual report 2015 I CIBEROBN